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2 "Jung-Hwan Cho"
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Review Article
Diabetes, obesity and metabolism
Glucocorticoid-Induced Hyperglycemia: A Neglected Problem
Jung-Hwan Cho, Sunghwan Suh
Endocrinol Metab. 2024;39(2):222-238.   Published online March 27, 2024
DOI: https://doi.org/10.3803/EnM.2024.1951
  • 1,395 View
  • 62 Download
AbstractAbstract PDFPubReader   ePub   
Glucocorticoids provide a potent therapeutic response and are widely used to treat a variety of diseases, including coronavirus disease 2019 (COVID-19) infection. However, the issue of glucocorticoid-induced hyperglycemia (GIH), which is observed in over one-third of patients treated with glucocorticoids, is often neglected. To improve the clinical course and prognosis of diseases that necessitate glucocorticoid therapy, proper management of GIH is essential. The key pathophysiology of GIH includes systemic insulin resistance, which exacerbates hepatic steatosis and visceral obesity, as well as proteolysis and lipolysis of muscle and adipose tissue, coupled with β-cell dysfunction. For patients on glucocorticoid therapy, risk stratification should be conducted through a detailed baseline evaluation, and frequent glucose monitoring is recommended to detect the onset of GIH, particularly in high-risk individuals. Patients with confirmed GIH who require treatment should follow an insulin-centered regimen that varies depending on whether they are inpatients or outpatients, as well as the type and dosage of glucocorticoid used. The ideal strategy to maintain normoglycemia while preventing hypoglycemia is to combine basal-bolus insulin and correction doses with a continuous glucose monitoring system. This review focuses on the current understanding and latest evidence concerning GIH, incorporating insights gained from the COVID-19 pandemic.
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Original Article
Thyroid
Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
Endocrinol Metab. 2018;33(2):260-267.   Published online June 21, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.2.260
  • 6,464 View
  • 128 Download
  • 37 Web of Science
  • 37 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

The incidence of thyroid nodules has increased worldwide in recent years. Thyroid dysfunction is a potential risk factor for hypercholesterolemia, cardiovascular disease, osteoporosis, arrhythmia, and neuropsychiatric disease. This study investigated the prevalence and annual incidence of thyroid nodules, hypothyroidism, and hyperthyroidism in Koreans.

Methods

In this nationwide population-based cohort study, 51,834,660 subjects were included using the National Health Information database from 2006 to 2015, after the exclusion of subjects with thyroid cancer.

Results

The prevalence in Korea in 2015 of thyroid nodules, hypothyroidism in patients taking thyroid hormone, and hyperthyroidism in patients undergoing treatment was 15.82/1,000 population, 15.94/1,000 population, and 2.76/1,000 population, respectively. All these diseases were more prevalent among women than among men. The number of incident cases of these three thyroid diseases steadily increased from 2006 to 2012, and then decreased through 2015. The incidence of thyroid nodules, hypothyroidism treated with thyroid hormone, and treated hyperthyroidism was 6.79/1,000 population, 1.76/1,000 population, and 0.55/1,000 population, respectively, in Korea in 2015. The use of methimazole continuously increased, from 33% of total antithyroid drug prescriptions in 2006 to 74.4% in 2015, and it became the most frequently prescribed antithyroid drug in Korea. In contrast, the use of propylthiouracil continuously decreased.

Conclusion

This was the first nationwide study of the prevalence and annual incidence of thyroid nodules, hypothyroidism, and hyperthyroidism to take into account recent changes and to include the current status of patients receiving treatment.

Citations

Citations to this article as recorded by  
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    Rheumatology.2024; 63(3): 630.     CrossRef
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    The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1095.     CrossRef
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    The Journal of Dermatology.2024; 51(3): 429.     CrossRef
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    Immunity, Inflammation and Disease.2023;[Epub]     CrossRef
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    Endocrine Pathology.2023; 34(2): 247.     CrossRef
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    Clinical Epidemiology.2023; Volume 15: 535.     CrossRef
  • Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study
    Hyemi Kwon, Kyung-Do Han, Bong-Sung Kim, Sun Joon Moon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Osteoporosis International.2023; 34(9): 1591.     CrossRef
  • Association of Thyroid Hormone Medication Adherence With Risk of Dementia
    Saemi Han, Seogsong Jeong, Seulggie Choi, Sun Jae Park, Kyae Hyung Kim, Gyeongsil Lee, Yoosun Cho, Joung Sik Son, Sang Min Park
    The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): e225.     CrossRef
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    Rheumatology International.2023; 44(3): 451.     CrossRef
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    Hyemi Kwon
    Endocrinology and Metabolism.2023; 38(4): 392.     CrossRef
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    Hwa Young Ahn, Sun Wook Cho, Mi Young Lee, Young Joo Park, Bon Seok Koo, Hang-Seok Chang, Ka Hee Yi
    Endocrinology and Metabolism.2023; 38(4): 436.     CrossRef
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    Scientific Reports.2023;[Epub]     CrossRef
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    Brazilian Journal of Otorhinolaryngology.2022; 88(6): 982.     CrossRef
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    Brain Communications.2022;[Epub]     CrossRef
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    Frontiers in Medicine.2022;[Epub]     CrossRef
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    Oral Diseases.2021; 27(6): 1443.     CrossRef
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    Chuyuan Wang, Yongze Li, Di Teng, Xiaoguang Shi, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Yanbo Li, Haiyi Chi, Eryuan Liao, Chao Liu, Libin Liu, Guijun Qin, Yingfen Qin, Huibiao Quan, Bingyin Shi, Hui Sun, Xulei Tang, Nanwei Tong, Gui
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    Epidemiology and Health.2021; 43: e2021018.     CrossRef
  • Prevalence of Hyperthyroidism and Hypothyroidism and its Correlation with Serum Antithyroglobulin among patients in Kirkuk-Iraq ‎
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